› 4rmd

X-ray diffraction
1.9Å resolution

Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with 9cUAB110 and coactivator peptide GRIP-1

Released:
DOI: 10.2210/pdb4rmd/pdb
PDB entry 4rmd coloured by chain, front view.
PDB entry 4rmd coloured by chain, side view.
PDB entry 4rmd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Atigadda VR, Xia G, Deshpande A, Wu L, Kedishvili N, Smith CD, Krontiras H, Bland KI, Grubbs CJ, Brouillette WJ, Muccio DD
J Med Chem 58 7763-74 (2015)
PMID: 26331194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 26.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 228-462; Coverage: 51%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 3SW 1 x 3SW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P43212
Unit cell:
a: 65.971Å b: 65.971Å c: 112.347Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.209 0.239
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

5 review citations

A review of the molecular design and biological activities of RXR agonists.
de Almeida et al. (2019)
4 more

3 mentions without citation

Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Atigadda et al. (2015)
2 more