› 4rss

X-ray diffraction
1.83Å resolution

Crystal structure of tyrosine-protein kinase SYK with an inhibitor

Released:
DOI: 10.2210/pdb4rss/pdb
PDB entry 4rss coloured by chain, front view.
PDB entry 4rss coloured by chain, side view.
PDB entry 4rss coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Choi JS, Hwang HJ, Kim SW, Lee BI, Lee J, Song HJ, Koh JS, Kim JH, Lee PH
Bioorg Med Chem Lett 25 4441-6 (2015)
PMID: 26384287

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155056 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 356-635; Coverage: 44%)
Gene name: SYK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 4MG 1 x 4MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 39.964Å b: 88.281Å c: 40.85Å
α: 90° β: 91.48° γ: 90°
R-values:
R R work R free
0.214 0.212 0.249
Expression system: Spodoptera frugiperda

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Citations

3 citation in other articles

Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets.
Meyer F. (2016)
2 more