› 4rtt

X-ray diffraction
1.87Å resolution

Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment

Released:
DOI: 10.2210/pdb4rtt/pdb
PDB entry 4rtt coloured by chain, front view.
PDB entry 4rtt coloured by chain, side view.
PDB entry 4rtt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.
Guez-Haddad J, Sporny M, Sasson Y, Gevorkyan-Airapetov L, Lahav-Mankovski N, Margulies D, Radzimanowski J, Opatowsky Y
Structure 23 1989-2000 (2015)
PMID: 26365803

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SLIT-ROBO Rho GTPase-activating protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75044 (Residues: 729-815; Coverage: 8%)
Gene names: ARHGAP34, FNBP2, KIAA0456, SRGAP2, SRGAP2A
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 31.3Å b: 52.54Å c: 92.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.221 0.259
Expression system: Escherichia coli

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Citations

4 review citations

Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases.
Huang et al. (2017)
3 more