› 4rtz

X-ray diffraction
0.98Å resolution

Crystal structure of the c-Src-SH3 domain in complex with the high affinity peptide VSL12

Released:
DOI: 10.2210/pdb4rtz/pdb
PDB entry 4rtz coloured by chain, front view.
PDB entry 4rtz coloured by chain, side view.
PDB entry 4rtz coloured by chain, top view.
Source organisms:
Entry authors: Camara-Artigas A, Bacarizo J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132647 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.91 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00523 (Residues: 85-141; Coverage: 11%)
Gene name: SRC
Sequence domains: SH3 domain
Structure domains: SH3 Domains
VSL12 peptide Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.32 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NI 1 x NI
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 32.904Å b: 41.046Å c: 44.066Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.144 0.143 0.158
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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