› 4rwd

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142083 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Delta-type opioid receptor; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 45.64 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P41143 (Residues: 39-338; Coverage: 81%)
Gene names: OPRD, OPRD1, cybC
Sequence domains:
bifunctional peptide Chains: G, H
Molecule details ›
Chains: G, H
Length: 5 amino acids
Theoretical weight: 661 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand OLA 7 x OLA
Ligand NA 2 x NA
Ligand OLC 3 x OLC
1 modified residue:
Ligand DI7 2 x DI7

Experiments and Validation Details

Entry percentile scores
X-ray source: SLAC LCLS BEAMLINE CXI
Spacegroup: C2
Unit cell:
a: 156.23Å b: 89.29Å c: 96.42Å
α: 90° β: 92.3° γ: 90°
R-values:
R R work R free
0.21 0.208 0.238
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

26 review citations

Advances in therapeutic peptides targeting G protein-coupled receptors.
Davenport et al. (2020)
25 more

30 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
29 more