› 4rxz

X-ray diffraction
1.55Å resolution

Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide

Released:
DOI: 10.2210/pdb4rxz/pdb
PDB entry 4rxz coloured by chain, front view.
PDB entry 4rxz coloured by chain, side view.
PDB entry 4rxz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of how stress-induced MDMX phosphorylation activates p53.
Chen X, Gohain N, Zhan C, Lu WY, Pazgier M, Lu W
Oncogene 35 1919-25 (2016)
PMID: 26148237

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127321 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 85 amino acids
Theoretical weight: 9.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15151 (Residues: 24-108; Coverage: 17%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain
12-MER PEPTIDE INHIBITOR Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P1
Unit cell:
a: 28.613Å b: 41.43Å c: 45.618Å
α: 103.32° β: 103.67° γ: 102.44°
R-values:
R R work R free
0.182 0.18 0.22
Expression system: Not provided

Quick links

Citations

3 review citations

Cross talk of tyrosine kinases with the DNA damage signaling pathways.
Mahajan et al. (2015)
2 more

3 mentions without citation

Interfacial Peptides as Affinity Modulating Agents of Protein-Protein Interactions.
Ershov et al. (2022)
2 more