› 4ry3

X-ray diffraction
2.8Å resolution

Crystal structure of human Fanconi-associated nuclease 1

Released:
DOI: 10.2210/pdb4ry3/pdb
PDB entry 4ry3 coloured by chain, front view.
PDB entry 4ry3 coloured by chain, side view.
PDB entry 4ry3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human Fanconi-associated nuclease 1.
Yan PX, Huo YG, Jiang T
Protein Cell 6 225-8 (2015)
PMID: 25547363

Function and Biology Details

Reaction catalysed: 
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195145 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fanconi-associated nuclease 1 Chain: A
Molecule details ›
Chain: A
Length: 648 amino acids
Theoretical weight: 73.85 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9Y2M0 (Residues: 371-1010; Coverage: 63%)
Gene names: FAN1, KIAA1018, MTMR15
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PT 1 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P213
Unit cell:
a: 161.082Å b: 161.082Å c: 161.082Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.243
Expression system: Komagataella pastoris

Quick links

Citations

1 review citation

Structural and functional relationships of FAN1.
Jin et al. (2017)
2 other articles

1 mention without citation

Crystal structure of human Fanconi-associated nuclease 1.
Yan et al. (2015)