› 4s0p

X-ray diffraction
3.25Å resolution

Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)

Released:
DOI: 10.2210/pdb4s0p/pdb
PDB entry 4s0p coloured by chain, front view.
PDB entry 4s0p coloured by chain, side view.
PDB entry 4s0p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E, Gavathiotis E
Mol Cell 63 485-97 (2016)
PMID: 27425408

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator BAX Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 21.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-192; Coverage: 100%)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 40.587Å b: 65.01Å c: 65.59Å
α: 90° β: 89.87° γ: 90°
R-values:
R R work R free
0.214 0.211 0.27
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
12 more

2 mentions without citation

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner et al. (2016)
1 more