› 4tt2

X-ray diffraction
2.5Å resolution

Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide

Released:
DOI: 10.2210/pdb4tt2/pdb
PDB entry 4tt2 coloured by chain, front view.
PDB entry 4tt2 coloured by chain, side view.
PDB entry 4tt2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee GR, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE
Biochem J 466 337-46 (2015)
PMID: 25486442

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165194 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like
Histone H4K5Ac Chain: P
Molecule details ›
Chain: P
Length: 6 amino acids
Theoretical weight: 604 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P42212
Unit cell:
a: 77.55Å b: 77.55Å c: 62.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.22 0.267
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

6 review citations

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali et al. (2018)
5 more

5 mentions without citation

Biological function and histone recognition of family IV bromodomain-containing proteins.
Lloyd et al. (2018)
4 more