› 4tyh

X-ray diffraction
3Å resolution

Ternary complex of P38 and MK2 with a P38 inhibitor

Released:
DOI: 10.2210/pdb4tyh/pdb
PDB entry 4tyh coloured by chain, front view.
PDB entry 4tyh coloured by chain, side view.
PDB entry 4tyh coloured by chain, top view.
Source organisms:
Entry authors: Cumming JG, Debreczeni JE, Edfeldt F, Evertsson F, Harrison M, Holdgate G, James M, Lamont S, Oldham K, Sullivan JE, Wells S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155651 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MAP kinase-activated protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 40.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49137 (Residues: 51-400; Coverage: 88%)
Gene name: MAPKAPK2
Sequence domains: Protein kinase domain
Structure domains:
Mitogen-activated protein kinase 14 Chain: B
Molecule details ›
Chain: B
Length: 348 amino acids
Theoretical weight: 39.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 6-353; Coverage: 97%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 39G 1 x 39G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41212
Unit cell:
a: 87.726Å b: 87.726Å c: 229.876Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.228 0.313
Expression system: Escherichia coli

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