› 4tyi

X-ray diffraction
3.4Å resolution

Structural analysis of the human Fibroblast Growth Factor Receptor 4

Released:
DOI: 10.2210/pdb4tyi/pdb
PDB entry 4tyi coloured by chain, front view.
PDB entry 4tyi coloured by chain, side view.
PDB entry 4tyi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the human fibroblast growth factor receptor 4 kinase.
Lesca E, Lammens A, Huber R, Augustin M
J Mol Biol 426 3744-3756 (2014)
PMID: 25219510

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22455 (Residues: 447-753; Coverage: 39%)
Gene names: FGFR4, JTK2, TKF
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 38O 1 x 38O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 65.9Å b: 65.9Å c: 182.262Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.281 0.277 0.34
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Advances and challenges in targeting FGFR signalling in cancer.
Babina et al. (2017)
7 more

2 mentions without citation

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.
Cocco et al. (2021)
1 more