› 4tz2

X-ray diffraction
1.7Å resolution

Fragment-Based Screening of the Bromodomain of ATAD2

Released:
DOI: 10.2210/pdb4tz2/pdb
PDB entry 4tz2 coloured by chain, front view.
PDB entry 4tz2 coloured by chain, side view.
PDB entry 4tz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fragment-based screening of the bromodomain of ATAD2.
Harner MJ, Chauder BA, Phan J, Fesik SW
J Med Chem 57 9687-92 (2014)
PMID: 25314628

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand TRS 1 x TRS
Ligand CL 2 x CL
Ligand 39R 1 x 39R
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 79.203Å b: 79.203Å c: 136.036Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.169 0.201
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Bromodomain biology and drug discovery.
Zaware et al. (2019)
11 more

3 mentions without citation

AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors.
Zhang et al. (2021)
2 more