› 4tz8

X-ray diffraction
2.15Å resolution

Structure of human ATAD2 bromodomain bound to fragment inhibitor

Released:
DOI: 10.2210/pdb4tz8/pdb
PDB entry 4tz8 coloured by chain, front view.
PDB entry 4tz8 coloured by chain, side view.
PDB entry 4tz8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fragment-based screening of the bromodomain of ATAD2.
Harner MJ, Chauder BA, Phan J, Fesik SW
J Med Chem 57 9687-92 (2014)
PMID: 25314628

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6PL18 (Residues: 981-1108; Coverage: 9%)
Gene names: ATAD2, L16, PRO2000
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand CL 1 x CL
Ligand 39U 1 x 39U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 79.942Å b: 79.942Å c: 138.259Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.198 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Bromodomain biology and drug discovery.
Zaware et al. (2019)
11 more

5 mentions without citation

AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors.
Zhang et al. (2021)
4 more