› 4u0i

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 35.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10721 (Residues: 563-693, 754-935; Coverage: 33%)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 0LI 1 x 0LI
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 70.032Å b: 70.032Å c: 129.212Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.204 0.239
Expression system: Spodoptera frugiperda

Quick links

Citations

34 review citations

Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies.
Tan et al. (2019)
33 more

17 mentions without citation

Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia.
Musumeci et al. (2018)
16 more