› 4u2m

X-ray diffraction
2.23Å resolution

Crystal structure of a complex of the Miz1- and BCL6 POZ domains.

Released:
DOI: 10.2210/pdb4u2m/pdb
PDB entry 4u2m coloured by chain, front view.
PDB entry 4u2m coloured by chain, side view.
PDB entry 4u2m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1.
Stead MA, Wright SC
Acta Crystallogr F Struct Biol Commun 70 1591-6 (2014)
PMID: 25484205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein; Zinc finger and BTB domain-containing protein 17 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 256 amino acids
Theoretical weight: 28.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13105 (Residues: 2-115; Coverage: 14%)
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, MIZ1, ZBTB17, ZBTB27, ZNF151, ZNF51, ZNF60
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 91.85Å b: 97.88Å c: 119.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 citation in other articles

Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner.
Nakayama et al. (2020)
8 more

2 mentions without citation

Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1.
Stead et al. (2014)
1 more