› 4u2v

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2 homologous antagonist/killer; Green fluorescent protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 35.42 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P42212 (Residues: 1-230; Coverage: 97%)
  • Canonical: Q16611 (Residues: 68-148; Coverage: 38%)
Gene names: BAK, BAK1, BCL2L7, CDN1, GFP
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CAC 6 x CAC
Ligand MPD 2 x MPD
1 modified residue:
Ligand CR2 4 x CR2

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 109.19Å b: 63.84Å c: 122.02Å
α: 90° β: 98.35° γ: 90°
R-values:
R R work R free
0.201 0.198 0.25
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
30 more

9 mentions without citation

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.
Moldoveanu et al. (2020)
8 more