› 4u3y

X-ray diffraction
1.45Å resolution

Apo Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Released:
DOI: 10.2210/pdb4u3y/pdb
PDB entry 4u3y coloured by chain, front view.
PDB entry 4u3y coloured by chain, side view.
PDB entry 4u3y coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Harris SF, Wu P, Coons M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 332 amino acids
Theoretical weight: 37.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95819 (Residues: 2-328; Coverage: 26%)
Gene names: HGK, KIAA0687, MAP4K4, NIK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 80.407Å b: 80.839Å c: 92.953Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.183 0.207
Expression system: Spodoptera frugiperda

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