› 4u54

X-ray diffraction
2.41Å resolution

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Released:
DOI: 10.2210/pdb4u54/pdb
PDB entry 4u54 coloured by chain, front view.
PDB entry 4u54 coloured by chain, side view.
PDB entry 4u54 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.
Holvey RS, Valkov E, Neal D, Stewart M, Abell C
ChemMedChem 10 1232-9 (2015)
PMID: 25899172

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156499 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 425 amino acids
Theoretical weight: 46.08 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 74-498; Coverage: 80%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand 3C5 1 x 3C5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 78.424Å b: 91.298Å c: 98.816Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.227
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein.
Nakada et al. (2015)
4 more

2 mentions without citation

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.
Holvey et al. (2015)
1 more