4u5n

X-ray diffraction
2.31Å resolution

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-156499 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 426 amino acids
Theoretical weight: 46.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 72-497; Coverage: 81%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 78.501Å b: 91.08Å c: 98.965Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.221
Expression system: Escherichia coli