› 4u5s

X-ray diffraction
2.12Å resolution

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Released:
DOI: 10.2210/pdb4u5s/pdb
PDB entry 4u5s coloured by chain, front view.
PDB entry 4u5s coloured by chain, side view.
PDB entry 4u5s coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.
Holvey RS, Valkov E, Neal D, Stewart M, Abell C
ChemMedChem 10 1232-9 (2015)
PMID: 25899172

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156499 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Importin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 426 amino acids
Theoretical weight: 46.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 72-497; Coverage: 81%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand 3D0 2 x 3D0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 79.63Å b: 91.33Å c: 102.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.231
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein.
Nakada et al. (2015)
5 more

1 mention without citation

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.
Holvey et al. (2015)