› 4u8z

X-ray diffraction
1.63Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 32.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 24-310; Coverage: 65%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MN 1 x MN
Ligand 3FE 1 x 3FE
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 99.11Å b: 59.02Å c: 61.81Å
α: 90° β: 93.76° γ: 90°
R-values:
R R work R free
0.192 0.19 0.222
Expression system: Escherichia coli

Quick links

Citations

22 review citations

LRRK2 Pathways Leading to Neurodegeneration.
Cookson MR. (2015)
21 more

6 mentions without citation

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition.
Kelly et al. (2018)
5 more