› 4u97

X-ray diffraction
2.65Å resolution

Crystal Structure of Asymmetric IRAK4 Dimer

Released:
DOI: 10.2210/pdb4u97/pdb
PDB entry 4u97 coloured by chain, front view.
PDB entry 4u97 coloured by chain, side view.
PDB entry 4u97 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly.
Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H
Mol Cell 55 891-903 (2014)
PMID: 25201411

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NWZ3 (Residues: 154-460; Coverage: 67%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand STU 2 x STU
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P6122
Unit cell:
a: 87.58Å b: 87.58Å c: 421.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.203 0.251
Expression system: Trichoplusia ni

Quick links

Citations

27 review citations

Toll-like Receptors and the Control of Immunity.
Fitzgerald et al. (2020)
26 more

7 mentions without citation

There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
Mace et al. (2021)
6 more