› 4uhr

X-ray diffraction
2.6Å resolution

Thermostabilised HUMAN A2a Receptor with CGS21680 bound

Released:
DOI: 10.2210/pdb4uhr/pdb
PDB entry 4uhr coloured by chain, front view.
PDB entry 4uhr coloured by chain, side view.
PDB entry 4uhr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.
Lebon G, Edwards PC, Leslie AG, Tate CG
Mol Pharmacol 87 907-15 (2015)
PMID: 25762024

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29274 (Residues: 1-317; Coverage: 77%)
Gene names: ADORA2, ADORA2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

1 bound ligand:
Ligand NGI 1 x NGI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 60.407Å b: 59.187Å c: 65.058Å
α: 90° β: 92.83° γ: 90°
R-values:
R R work R free
0.261 0.259 0.312
Expression system: Trichoplusia ni

Quick links

Citations

13 review citations

Medicinal chemistry of adenosine, P2Y and P2X receptors.
Jacobson et al. (2016)
12 more

29 mentions without citation

Structural Basis for G Protein-Coupled Receptor Activation.
Manglik et al. (2017)
28 more