› 4um8

X-ray diffraction
2.85Å resolution

Crystal structure of alpha V beta 6

Released:
DOI: 10.2210/pdb4um8/pdb
PDB entry 4um8 coloured by chain, front view.
PDB entry 4um8 coloured by chain, side view.
PDB entry 4um8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of integrin β-subunit specificity for latent TGF-β.
Dong X, Hudson NE, Lu C, Springer TA
Nat Struct Mol Biol 21 1091-6 (2014)
PMID: 25383667

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139209 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (10 distinct):
Integrin alpha-V heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 681 amino acids
Theoretical weight: 75.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P06756 (Residues: 31-625; Coverage: 58%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-6 Chains: B, D
Molecule details ›
Chains: B, D
Length: 788 amino acids
Theoretical weight: 86.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18564 (Residues: 1-788; Coverage: 100%)
Gene name: ITGB6
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
7 bound ligands:
Ligand CL 3 x CL
Ligand SO4 3 x SO4
Ligand NI 1 x NI
Ligand CA 10 x CA
Ligand CAC 2 x CAC
Ligand MG 2 x MG
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 184.45Å b: 170.01Å c: 102.39Å
α: 90° β: 98.68° γ: 90°
R-values:
R R work R free
0.24 0.238 0.281
Expression system: Homo sapiens

Quick links

Citations

24 review citations

Fibrosis: from mechanisms to medicines.
Henderson et al. (2020)
23 more

8 mentions without citation

Potential entry receptors for human γ-herpesvirus into epithelial cells: A plausible therapeutic target for viral infections.
Rani et al. (2021)
7 more