› 4use

X-ray diffraction
2.65Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand R09 2 x R09
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 62.04Å b: 50.25Å c: 133.71Å
α: 90° β: 101.16° γ: 90°
R-values:
R R work R free
0.226 0.225 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

Drug repurposing: progress, challenges and recommendations.
Pushpakom et al. (2019)
28 more

1 mention without citation

Druggable exosites of the human kino-pocketome.
Nicola et al. (2020)