› 4usl

X-ray diffraction
1.65Å resolution

The X-ray structure of calcium bound human sorcin

Released:
DOI: 10.2210/pdb4usl/pdb
PDB entry 4usl coloured by chain, front view.
PDB entry 4usl coloured by chain, side view.
PDB entry 4usl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of Sorcin-mediated calcium-dependent signal transduction.
Ilari A, Fiorillo A, Poser E, Lalioti VS, Sundell GN, Ivarsson Y, Genovese I, Colotti G
Sci Rep 5 16828 (2015)
PMID: 26577048

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151779 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sorcin Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 21.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30626 (Residues: 1-198; Coverage: 100%)
Gene name: SRI
Sequence domains:
Structure domains: EF-hand
Sorcin Chain: D
Molecule details ›
Chain: D
Length: 32 amino acids
Theoretical weight: 3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30626 (Residues: 1-32; Coverage: 16%)
Gene name: SRI

Ligands and Environments

3 bound ligands:
Ligand CA 3 x CA
Ligand SO4 1 x SO4
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2221
Unit cell:
a: 52.369Å b: 111.58Å c: 60.479Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Sorcin a Potential Molecular Target for Cancer Therapy.
Shabnam et al. (2018)
2 more

1 mention without citation

Structural basis of Sorcin-mediated calcium-dependent signal transduction.
Ilari et al. (2015)