› 4uu9

X-ray diffraction
2.12Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208336 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
MEDI7814 Chains: A, H
Molecule details ›
Chains: A, H
Length: 123 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
Structure domains: Immunoglobulins
MEDI7814 Chains: B, L
Molecule details ›
Chains: B, L
Length: 111 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
Structure domains: Immunoglobulins
C5a anaphylatoxin Chains: C, D
Molecule details ›
Chains: C, D
Length: 75 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01031 (Residues: 678-751; Coverage: 5%)
Gene names: C5, CPAMD4
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 56.854Å b: 117.472Å c: 126.457Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.202
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Antibody Structure and Function: The Basis for Engineering Therapeutics.
Chiu et al. (2019)
2 more

3 mentions without citation

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
Colley et al. (2018)
2 more