› 4uyi

X-ray diffraction
1.86Å resolution

Crystal structure of the BTB domain of human SLX4 (BTBD12)

Released:
DOI: 10.2210/pdb4uyi/pdb
PDB entry 4uyi coloured by chain, front view.
PDB entry 4uyi coloured by chain, side view.
PDB entry 4uyi coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pinkas DM, Sanvitale CE, Strain-Damerell C, Fairhead M, Wang D, Tallant C, Cooper CDO, Sorrell FJ, Kopec J, Chaikuad A, Fitzpatrick F, Pike ACW, Hozjan V, Ying Z, Roos AK, Savitsky P, Bradley A, Nowak R, Filippakopoulos P, Krojer T, Burgess-Brown NA, Marsden BD, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184928 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Structure-specific endonuclease subunit SLX4 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 16.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8IY92 (Residues: 668-796; Coverage: 7%)
Gene names: BTBD12, KIAA1784, KIAA1987, SLX4
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: R32
Unit cell:
a: 142.49Å b: 142.49Å c: 50.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.18 0.194
Expression system: Escherichia coli BL21

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