4uzq

X-ray diffraction
1.5Å resolution

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH O-PALMITOLEOYL SERINE - CRYSTAL FORM IX - 1.5A

Released:

Function and Biology Details

Reaction catalysed:
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H(2)O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-126381 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Palmitoleoyl-protein carboxylesterase NOTUM Chain: A
Molecule details ›
Chain: A
Length: 386 amino acids
Theoretical weight: 43.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P988 (Residues: 81-451; Coverage: 78%)
Gene names: NOTUM, OK/SW-CL.30
Sequence domains: Pectinacetylesterase
Protein Wnt-7a Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 750 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00755 (Residues: 202-209; Coverage: 3%)
Gene name: WNT7A

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Unit cell:
a: 50.513Å b: 69.35Å c: 120.967Å
α: 90° β: 92.28° γ: 90°
R-values:
R R work R free
0.129 0.128 0.178
Expression systems:
  • Homo sapiens
  • Not provided