› 4v05

X-ray diffraction
2.57Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand EDO 5 x EDO
Ligand 66T 2 x 66T
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 208.78Å b: 57.48Å c: 65.58Å
α: 90° β: 107.64° γ: 90°
R-values:
R R work R free
0.196 0.192 0.256
Expression system: Escherichia coli

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Citations

8 review citations

Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches.
Shea et al. (2016)
7 more

15 mentions without citation

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting.
Farrell et al. (2018)
14 more