Function and Biology Details
Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-124199 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Histone-lysine N-methyltransferase EZH2
Molecule details ›
Chains: A, B
Length: 643 amino acids
Theoretical weight: 72.94 KDa
Source organism: Anolis carolinensis
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 643 amino acids
Theoretical weight: 72.94 KDa
Source organism: Anolis carolinensis
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
G1KPH4 (Residues: 16-514, 538-773; Coverage: 81%)
Sequence domains:
Polycomb protein EED
Molecule details ›
Chains: E, F
Length: 362 amino acids
Theoretical weight: 41.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Length: 362 amino acids
Theoretical weight: 41.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: O75530 (Residues: 81-441; Coverage: 82%)
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Polycomb protein SUZ12
Molecule details ›
Chains: S, T
Length: 191 amino acids
Theoretical weight: 22.27 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: VEFS-Box of polycomb protein
Length: 191 amino acids
Theoretical weight: 22.27 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q15022 (Residues: 545-725; Coverage: 25%)
Sequence domains: VEFS-Box of polycomb protein
