› 4wco

X-ray diffraction
2.46Å resolution

Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A

Released:
DOI: 10.2210/pdb4wco/pdb
PDB entry 4wco coloured by chain, front view.
PDB entry 4wco coloured by chain, side view.
PDB entry 4wco coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of extracellular domain of human lectin-like transcript 1 (LLT1), the ligand for natural killer receptor-P1A.
Kita S, Matsubara H, Kasai Y, Tamaoki T, Okabe Y, Fukuhara H, Kamishikiryo J, Krayukhina E, Uchiyama S, Ose T, Kuroki K, Maenaka K
Eur J Immunol 45 1605-13 (2015)
PMID: 25826155

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 2 member D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 122 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UHP7 (Residues: 71-191; Coverage: 63%)
Gene names: CLAX, CLEC2D, LLT1, OCIL
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

3 bound ligands:
Ligand ZN 7 x ZN
Ligand ACT 3 x ACT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21212
Unit cell:
a: 82.379Å b: 84.658Å c: 53.422Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.257
Expression system: Escherichia coli BL21

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Citations

1 review citation

LLT1-CD161 Interaction in Cancer: Promises and Challenges.
Braud et al. (2022)
8 other articles