› 4whu

X-ray diffraction
2.11Å resolution

BROMO domain of CREB binding protein

Released:
DOI: 10.2210/pdb4whu/pdb
PDB entry 4whu coloured by chain, front view.
PDB entry 4whu coloured by chain, side view.
PDB entry 4whu coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Liu S

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 14.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q92793 (Residues: 1081-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 3OT 1 x 3OT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 25.284Å b: 43.317Å c: 51.387Å
α: 90° β: 98.68° γ: 90°
R-values:
R R work R free
0.21 0.208 0.261
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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