› 4wln

X-ray diffraction
2.28Å resolution

Crystal structure of apo MDH2

Released:
DOI: 10.2210/pdb4wln/pdb
PDB entry 4wln coloured by chain, front view.
PDB entry 4wln coloured by chain, side view.
PDB entry 4wln coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Eo YM, Han BG, Ahn HC

Function and Biology Details

Reaction catalysed: 
(S)-malate + NAD(+) = oxaloacetate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 340 amino acids
Theoretical weight: 35.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40926 (Residues: 20-338; Coverage: 94%)
Gene name: MDH2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 12 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 59.919Å b: 151.271Å c: 155.114Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.246
Expression system: Escherichia coli

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