› 4wmy

X-ray diffraction
1.6Å resolution

Structure of Human intelectin-1 in complex with allyl-beta-galactofuranose

Released:
DOI: 10.2210/pdb4wmy/pdb
PDB entry 4wmy coloured by chain, front view.
PDB entry 4wmy coloured by chain, side view.
PDB entry 4wmy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Recognition of microbial glycans by human intelectin-1.
Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL
Nat Struct Mol Biol 22 603-10 (2015)
PMID: 26148048

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186749 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intelectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WWA0 (Residues: 29-313; Coverage: 97%)
Gene names: INTL, ITLN, ITLN1, LFR, UNQ640/PRO1270

Ligands and Environments

2 bound ligands:
Ligand CA 6 x CA
Ligand 3S6 2 x 3S6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P213
Unit cell:
a: 117.865Å b: 117.865Å c: 117.865Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.155 0.18
Expression system: Homo sapiens

Quick links

Citations

20 review citations

Biological roles of glycans.
Varki A. (2017)
19 more

12 mentions without citation

Recognition of microbial glycans by soluble human lectins.
Wesener et al. (2017)
11 more