› 4wn5

X-ray diffraction
1.15Å resolution

Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol

Released:
DOI: 10.2210/pdb4wn5/pdb
PDB entry 4wn5 coloured by chain, front view.
PDB entry 4wn5 coloured by chain, side view.
PDB entry 4wn5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Fala AM, Oliveira JF, Adamoski D, Aricetti JA, Dias MM, Dias MVB, Sforça ML, Lopes-de-Oliveira PS, Rocco SA, Caldana C, Dias SMG, Ambrosio ALB
Sci Rep 5 12698 (2015)
PMID: 26237540

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195149 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hypoxia-inducible factor 3-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 12.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2N7 (Residues: 237-347; Coverage: 17%)
Gene names: BHLHE17, HIF3A, MOP7, PASD7
Sequence domains: PAS domain
Structure domains: PAS domain

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand MVC 2 x MVC
Ligand P6G 5 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Unit cell:
a: 52.65Å b: 53.89Å c: 67.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.123 0.122 0.141
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Hypoxia-inducible factor 3 biology: complexities and emerging themes.
Duan C. (2016)
5 other articles

7 mentions without citation

Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection.
Cheng et al. (2017)
6 more