› 4wne

X-ray diffraction
2Å resolution

Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 2.0 Angstrom resolution

Released:
DOI: 10.2210/pdb4wne/pdb
PDB entry 4wne coloured by chain, front view.
PDB entry 4wne coloured by chain, side view.
PDB entry 4wne coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.
Takayanagi H, Yuzawa S, Sumimoto H
Acta Crystallogr F Struct Biol Commun 71 175-83 (2015)
PMID: 25664792

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160497 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G-protein-signaling modulator 2 Chain: A
Molecule details ›
Chain: A
Length: 406 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P81274 (Residues: 20-421; Coverage: 59%)
Gene names: GPSM2, LGN
Sequence domains:
Structure domains: Tetratricopeptide repeat domain
FERM and PDZ domain-containing protein 4 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 3.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14CM0 (Residues: 987-1011; Coverage: 2%)
Gene names: FRMPD4, KIAA0316, PDZD10, PDZK10

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P6122
Unit cell:
a: 91.784Å b: 91.784Å c: 176.783Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

6 citation in other articles

Molecular mechanism for the regulation of yeast separase by securin.
Luo et al. (2017)
5 more

1 mention without citation

Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.
Takayanagi et al. (2015)