Function and Biology Details
Reactions catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140112 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin carboxyl-terminal hydrolase 7
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 43.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: ICP0-binding domain of Ubiquitin-specific protease 7
Length: 375 amino acids
Theoretical weight: 43.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q93009 (Residues: 514-514, 535-888; Coverage: 32%)
Sequence domains: ICP0-binding domain of Ubiquitin-specific protease 7
E3 ubiquitin-protein ligase ICP0
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.32 KDa
Source organism: Human alphaherpesvirus 1 strain 17
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.32 KDa
Source organism: Human alphaherpesvirus 1 strain 17
Expression system: Not provided
UniProt:
- Canonical: P08393 (Residues: 617-627; Coverage: 1%)
