› 4wu5

X-ray diffraction
2.4Å resolution

HLA-A24 in complex with HIV-1 Nef134-8(wt)

Released:
DOI: 10.2210/pdb4wu5/pdb
PDB entry 4wu5 coloured by chain, front view.
PDB entry 4wu5 coloured by chain, side view.
PDB entry 4wu5 coloured by chain, top view.
Source organisms:
Entry authors: Shimizu A, Yamagata A, Fukai S, Iwamoto A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137651 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
C-terminal core protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 8 amino acids
Theoretical weight: 1.04 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04601 (Residues: 134-141; Coverage: 4%)
Gene name: nef

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 57.687Å b: 67.07Å c: 117.727Å
α: 90° β: 99.01° γ: 90°
R-values:
R R work R free
0.233 0.231 0.271
Expression systems:
  • Escherichia coli
  • Not provided

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