› 4wyv

X-ray diffraction
3Å resolution

Crystal Structure of Human Translin in Open Conformation

Released:
DOI: 10.2210/pdb4wyv/pdb
PDB entry 4wyv coloured by chain, front view.
PDB entry 4wyv coloured by chain, side view.
PDB entry 4wyv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel open-barrel structure of octameric translin reveals a potential RNA entryway.
Eliahoo E, Marx A, Manor H, Alian A
J Mol Biol 427 756-762 (2015)
PMID: 25433126

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 240 amino acids
Theoretical weight: 27.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15631 (Residues: 1-228; Coverage: 100%)
Gene name: TSN
Sequence domains: Translin family
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P41212
Unit cell:
a: 82.308Å b: 82.308Å c: 635.164Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.272
Expression system: Escherichia coli

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Citations

2 review citations

Translin: A multifunctional protein involved in nucleic acid metabolism.
Gupta et al. (2019)
1 more