› 4x0s

X-ray diffraction
2.03Å resolution

Hexamer formed by a macrocycle containing a sequence from beta-2-microglobulin (63-69).

Released:
DOI: 10.2210/pdb4x0s/pdb
PDB entry 4x0s coloured by chain, front view.
PDB entry 4x0s coloured by chain, side view.
PDB entry 4x0s coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin.
Spencer RK, Kreutzer AG, Salveson PJ, Li H, Nowick JS
J Am Chem Soc 137 6304-11 (2015)
PMID: 25915729

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin form pI 5.3 Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.98 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 83-89; Coverage: 7%)
Gene names: B2M, CDABP0092, HDCMA22P

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand SO4 1 x SO4
Ligand NA 1 x NA
3 modified residues:
Ligand ORN 2 x ORN
Ligand PHI 1 x PHI
Ligand MAA 1 x MAA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: R32
Unit cell:
a: 51.065Å b: 51.065Å c: 31.423Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.165 0.202
Expression system: Not provided

Quick links

Citations

7 review citations

Small molecule probes of protein aggregation.
Young et al. (2017)
6 more

1 mention without citation

X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin.
Spencer et al. (2015)