4x3e

X-ray diffraction
2.3Å resolution

Crystal structure of EED in complex with a trimethylated Jarid2 peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-131021 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polycomb protein EED Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 42.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75530 (Residues: 77-441; Coverage: 83%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: synthetic construct

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 49.419Å b: 58.144Å c: 127.042Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.224
Expression systems:
  • Escherichia coli
  • synthetic construct