› 4xaq

X-ray diffraction
2.21Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 503 amino acids
Theoretical weight: 55.71 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q14416 (Residues: 2-493; Coverage: 56%)
Gene names: GPRC1B, GRM2, MGLUR2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand 40F 2 x 40F
Ligand SO4 2 x SO4
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 81.644Å b: 159.652Å c: 93.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.225
Expression system: unidentified baculovirus

Quick links

Citations

5 review citations

Covalent allosteric modulation: An emerging strategy for GPCRs drug discovery.
Bian et al. (2020)
4 more

2 mentions without citation

Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Zhang et al. (2016)
1 more