› 4xar

X-ray diffraction
2.26Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.78 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q14832 (Residues: 2-508; Coverage: 57%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand 40F 1 x 40F
Ligand IOD 8 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P3221
Unit cell:
a: 80.338Å b: 80.338Å c: 155.688Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.197 0.224
Expression system: unidentified baculovirus

Quick links

Citations

5 review citations

Covalent allosteric modulation: An emerging strategy for GPCRs drug discovery.
Bian et al. (2020)
4 more

1 mention without citation

In Silico Analysis of the Association Relationship between Neuroprotection and Flavors of Traditional Chinese Medicine Based on the mGluRs.
Zhang et al. (2018)