› 4xbl

X-ray diffraction
1.93Å resolution

Crystal Structure of Human Galectin-1 in Complex with Type 1 N-acetyllactosamine

Released:
DOI: 10.2210/pdb4xbl/pdb
PDB entry 4xbl coloured by chain, front view.
PDB entry 4xbl coloured by chain, side view.
PDB entry 4xbl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for GalĪ²1-3/4GlcNAc.
Hsieh TJ, Lin HY, Tu Z, Huang BS, Wu SC, Lin CH
PLoS One 10 e0125946 (2015)
PMID: 25945972

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09382 (Residues: 1-135; Coverage: 100%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
2 modified residues:
Ligand CSO 4 x CSO
Ligand CME 6 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 43.265Å b: 58.211Å c: 111.401Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.235
Expression system: Escherichia coli

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Citations

4 review citations

Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis.
Sindrewicz et al. (2016)
3 more

2 mentions without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)
1 more