› 4xbn

X-ray diffraction
2.21Å resolution

Crystal Structure of Human Galectin-3 CRD in Complex with Type 1 N-acetyllactosamine

Released:
DOI: 10.2210/pdb4xbn/pdb
PDB entry 4xbn coloured by chain, front view.
PDB entry 4xbn coloured by chain, side view.
PDB entry 4xbn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc.
Hsieh TJ, Lin HY, Tu Z, Huang BS, Wu SC, Lin CH
PLoS One 10 e0125946 (2015)
PMID: 25945972

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 113-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 37.07Å b: 57.632Å c: 63.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.164 0.202
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis.
Sindrewicz et al. (2016)
4 more

5 mentions without citation

Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc.
Hsieh et al. (2015)
4 more