› 4xcs

X-ray diffraction
2.1Å resolution

Human peroxiredoxin-1 C83S mutant

Released:
DOI: 10.2210/pdb4xcs/pdb
PDB entry 4xcs coloured by chain, front view.
PDB entry 4xcs coloured by chain, side view.
PDB entry 4xcs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Dimeric Human Peroxiredoxin-1 C83S Mutant
Cho KJ, Park Y, Khan TG, Lee J-H, Kim S, Seok JH, Chung YB, Cho AE, Choi Y, Chang T-S, Kim KH
Bull.Korean Chem.Soc. 36 1543-1545 (2015)

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 219 amino acids
Theoretical weight: 24.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06830 (Residues: 1-199; Coverage: 100%)
Gene names: PAGA, PAGB, PRDX1, TDPX2
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand CPS 3 x CPS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: C2
Unit cell:
a: 138.788Å b: 80.128Å c: 125.618Å
α: 90° β: 89.99° γ: 90°
R-values:
R R work R free
0.178 0.176 0.222
Expression system: Escherichia coli

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