› 4xcx

X-ray diffraction
2.84Å resolution

METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE

Released:
DOI: 10.2210/pdb4xcx/pdb
PDB entry 4xcx coloured by chain, front view.
PDB entry 4xcx coloured by chain, side view.
PDB entry 4xcx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Zeng H, Dong A, Li Y, Wernimont A, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small RNA 2'-O-methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5T8I9 (Residues: 14-262; Coverage: 63%)
Gene names: C1orf59, HENMT1
Sequence domains: Methyltransferase domain
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
Ligand SAH 1 x SAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6322
Unit cell:
a: 166.025Å b: 166.025Å c: 74.478Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.225 0.249
Expression system: Escherichia coli BL21(DE3)

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