› 4xfs

X-ray diffraction
1.91Å resolution

Structure of IL-18 SER Mutant I

Released:
DOI: 10.2210/pdb4xfs/pdb
PDB entry 4xfs coloured by chain, front view.
PDB entry 4xfs coloured by chain, side view.
PDB entry 4xfs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallization of interleukin-18 for structure-based inhibitor design.
Krumm B, Meng X, Xiang Y, Deng J
Acta Crystallogr F Struct Biol Commun 71 710-7 (2015)
PMID: 26057800

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-18 Chains: A, B
Molecule details ›
Chains: A, B
Length: 157 amino acids
Theoretical weight: 17.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14116 (Residues: 37-193; Coverage: 81%)
Gene names: IGIF, IL18, IL1F4
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand DMS 5 x DMS
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 32.982Å b: 42.258Å c: 52.343Å
α: 77.8° β: 83.63° γ: 67.13°
R-values:
R R work R free
0.181 0.178 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Interleukin-18 and IL-18BP in inflammatory dermatological diseases.
Wang et al. (2023)

2 mentions without citation

Crystallization of interleukin-18 for structure-based inhibitor design.
Krumm et al. (2015)
1 more