› 4xhk

X-ray diffraction
1.9Å resolution

PIM1 kinase in complex with Compound 1s

Released:
DOI: 10.2210/pdb4xhk/pdb
PDB entry 4xhk coloured by chain, front view.
PDB entry 4xhk coloured by chain, side view.
PDB entry 4xhk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of low-nanomolar PIM kinase inhibitors.
Ishchenko A, Zhang L, Le Brazidec JY, Fan J, Chong JH, Hingway A, Raditsis A, Singh L, Elenbaas B, Hong VS, Marcotte D, Silvian L, Enyedy I, Chao J
Bioorg Med Chem Lett 25 474-80 (2015)
PMID: 25575657

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: B
Molecule details ›
Chain: B
Length: 315 amino acids
Theoretical weight: 35.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 1-313; Coverage: 100%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 3YR 1 x 3YR
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P65
Unit cell:
a: 96.99Å b: 96.99Å c: 80.772Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.158 0.156 0.184
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Pim Kinases: Important Regulators of Cardiovascular Disease.
Nock et al. (2023)
9 other articles

2 mentions without citation

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting.
Buettner et al. (2019)
1 more